TY - JOUR
T1 - One-year change in cerebral glucose metabolism in patients with Alzheimer's disease
AU - Hirono, Nobutsugu
AU - Hashimoto, Mamoru
AU - Ishii, Kazunari
AU - Kazui, Hiroaki
AU - Mori, Etsuro
PY - 2004/1/1
Y1 - 2004/1/1
N2 - By using [18F]-2-fluoro-deoxy-D-glucose and positron emission tomography, the authors studied changes in regional glucose metabolism after a 1-year interval in patients with mild Alzheimer's disease (AD). Glucose metabolism declined over time in the bilateral precuneus and posterior cingulate gyri and in the frontal, temporal, and parietal cortices. Glucose metabolism in these regions may be a useful measure of the progression of AD and a valid surrogate outcome measure of clinical drug trials.
AB - By using [18F]-2-fluoro-deoxy-D-glucose and positron emission tomography, the authors studied changes in regional glucose metabolism after a 1-year interval in patients with mild Alzheimer's disease (AD). Glucose metabolism declined over time in the bilateral precuneus and posterior cingulate gyri and in the frontal, temporal, and parietal cortices. Glucose metabolism in these regions may be a useful measure of the progression of AD and a valid surrogate outcome measure of clinical drug trials.
UR - http://www.scopus.com/inward/record.url?scp=10644240740&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=10644240740&partnerID=8YFLogxK
U2 - 10.1176/jnp.16.4.488
DO - 10.1176/jnp.16.4.488
M3 - Article
C2 - 15616176
AN - SCOPUS:10644240740
VL - 16
SP - 488
EP - 492
JO - Journal of Neuropsychiatry and Clinical Neurosciences
JF - Journal of Neuropsychiatry and Clinical Neurosciences
SN - 0895-0172
IS - 4
ER -
