One-year change in cerebral glucose metabolism in patients with Alzheimer's disease

Nobutsugu Hirono, Mamoru Hashimoto, Kazunari Ishii, Hiroaki Kazui, Etsuro Mori

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

By using [18F]-2-fluoro-deoxy-D-glucose and positron emission tomography, the authors studied changes in regional glucose metabolism after a 1-year interval in patients with mild Alzheimer's disease (AD). Glucose metabolism declined over time in the bilateral precuneus and posterior cingulate gyri and in the frontal, temporal, and parietal cortices. Glucose metabolism in these regions may be a useful measure of the progression of AD and a valid surrogate outcome measure of clinical drug trials.

Original languageEnglish
Pages (from-to)488-492
Number of pages5
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume16
Issue number4
DOIs
Publication statusPublished - 2004 Jan 1

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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