One-step generation of engineered drug-laden poly(lactic- Co -Glycolic acid) micropatterned with Teflon chips for potential application in tendon restoration

Xuetao Shi, Yihua Zhao, Jianhua Zhou, Song Chen, Hongkai Wu

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract

    Regulating cellular behaviors such as cellular spatial arrangement and cellular phenotype is critical for managing tissue microstructure and biological function for engineered tissue regeneration. We herein pattern drug-laden poly(lactic-co-glycolic acid) (PLGA) into grooves using novel Teflon stamps (that possess excellent properties of resistance to harsh organic solvents and molecular adsorption) for engineered tendon-repair therapeutics. The drug release and biological properties of melatonin-laden PLGA grooved micropatterns are investigated. The results reveal that fibroblasts cultured on the melatonin-laden PLGA groove micropatterns not only display significant cell alignment that mimics the cell behavior in native tendon, but also promote the secretion of a major extracellular matrix in tendon, type I collagen, indicating great potential for the engineering of functional tendon regeneration.

    Original languageEnglish
    Pages (from-to)10583-10590
    Number of pages8
    JournalACS Applied Materials and Interfaces
    Volume5
    Issue number21
    DOIs
    Publication statusPublished - 2013 Nov 13

    Keywords

    • Teflon
    • melatonin
    • micropatterning
    • poly(lactic- co -glycolic acid)
    • tendon

    ASJC Scopus subject areas

    • Materials Science(all)

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