Abstract
We have developed a facile one-step conversion of 2-deoxy-D-glucose to form a disubstituted cyclopentenone through catalyst-free hydrothermal reaction under mild conditions. The use of 2-deoxy-D-glucose in one-pot conversion is to provide the formation of a carbon five-membered ring instead of the common biomass-derived furans such as furfural, 5-HMF, etc. The cyclopentenone has a potential to be a building block for the preparation of chemical products. As one example, we successfully demonstrated the synthesis of prostaglandin E1 methyl ester.
Original language | English |
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Pages (from-to) | 1691-1696 |
Number of pages | 6 |
Journal | Bulletin of the Chemical Society of Japan |
Volume | 91 |
Issue number | 12 |
DOIs | |
Publication status | Published - 2018 Jan 1 |
Keywords
- Biomass
- Hydrothermal reaction
- Total synthesis
ASJC Scopus subject areas
- Chemistry(all)