Abstract
Substituted chiral hydrindanes were synthesized as single isomers in almost enantiopure forms through a one-pot process that proceeds via the diphenylprolinol silyl ether mediateddomino Michael/Michael reaction of α,β-unsaturated aldehydes and 3-hexene-2,5-dione, and a subsequent intramolecular aldol condensation of the generated cyclopentanone intermediate.
| Original language | English |
|---|---|
| Pages (from-to) | 867-869 |
| Number of pages | 3 |
| Journal | Chemistry Letters |
| Volume | 49 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2020 Jul |
Keywords
- Domino reaction
- Michael reaction
- Organocatalyst
ASJC Scopus subject areas
- Chemistry(all)
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Cite this
Umekubo, N., Iwata, R., & Hayashi, Y. (2020). One-pot Synthesis of Chiral cis-Hydrindanes via Diphenylprolinol Silyl Ether Mediated Domino Reaction and Aldol Condensation. Chemistry Letters, 49(7), 867-869. https://doi.org/10.1246/cl.200297