One-pot reductive cleavage of exo-olefin to methylene with a mild ozonolysis-Clemmensen reduction sequence

Shu Xu, Takayuki Toyama, Jun Nakamura, Hirokazu Arimoto

    Research output: Contribution to journalArticlepeer-review

    20 Citations (Scopus)

    Abstract

    A one-pot exo-olefin reductive cleavage was for the first time developed. The reaction could proceed under a mild condition avoiding the use of hazardous and expensive reagents. Meanwhile, a TMSCl-mediated Clemmensen reduction in alcoholic solvent was also examined.

    Original languageEnglish
    Pages (from-to)4534-4537
    Number of pages4
    JournalTetrahedron Letters
    Volume51
    Issue number34
    DOIs
    Publication statusPublished - 2010 Aug 25

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

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