Abstract
One-pot regio- and stereospecific synthesis of chitoheptaose ((GlcNAc) 7) has been achieved by using chitopentaose ((GlcNAc) 5) and chitobiose ((GlcNAc) 2) as starting materials. The key intermediate, 1,2-oxazoline derivative of (GlcNAc) 5, could be directly prepared in water and successfully transglycosylated to (GlcNAc) 2 catalyzed by a mutant chitinase with lower hydrolyzing activity.
Original language | English |
---|---|
Pages (from-to) | 689-690 |
Number of pages | 2 |
Journal | Chemistry Letters |
Volume | 41 |
Issue number | 7 |
DOIs | |
Publication status | Published - 2012 |
ASJC Scopus subject areas
- Chemistry(all)