Oncogenic cell cycle start control

Shigeki Jinno, Jie Lin, Mika Yageta, Hiroto Okayama

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

The ability to proliferate in the absence of anchorage is a fundamental attribute of cancer cells, yet how it is acquired is one central problem in cancer biology. By utilizing growth factor-transformable NRK cells and its insensitive mutants, we recently found that oncogenic stimulation invokes Cdk6 to participate in a critical step of the cell cycle start, but not via the regulation of its catalytic activity and that Cdk6 participation closely correlates with the anchorage-independent growth ability. Since many hematopoietic cells employ predominantly Cdk6 for the cell cycle start and perform anchorage-independent growth by nature, this finding raises the possibility that the mechanism by which oncogenic stimulation invokes anchorage-independent growth of NRK cells is similar to the one used for hematopoietic cell proliferation. We discuss this novel mechanism and its implication.

Original languageEnglish
Pages (from-to)23-29
Number of pages7
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume477
Issue number1-2
DOIs
Publication statusPublished - 2001 Jun 2
Externally publishedYes

Keywords

  • Anchorage-independent
  • Hematopoietic cell
  • Oncogenic stimulation

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

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