Once daily versus every two week multidose ofloxacin in patients with acute exacerbations of chronic respiratory disease

A. Watanabe

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Two different oral ofloxacin regimens, daily single-dose treatment with 200 mg (Regimen I) and every two week multidose treatment with 3×200 mg/day (Regimen II), were compared to evaluate the efficacy of quinolone regimens in controlling acute exacerbations of chronic respiratory tract infections. Fifty-one patients were evaluated in the study: 28 in Regimen I and 23 in Regimen II. The corrected mean incidence of exacerbation per case during the six months before and during the study was reduced from 2.45 to 0.48 in Regimen I, and from 2.79 to 1.0 in Regimen II. The development of resistant strains was not found to be a problem. We conclude that the long-term administration of new quinolones, especially the daily single-dose regimen with 200 mg of ofloxacin, is useful in controlling acute exacerbations of chronic respiratory tract infections.

    Original languageEnglish
    Pages (from-to)S384-S387
    JournalInfection
    Volume19
    Issue number7 Supplement
    DOIs
    Publication statusPublished - 1991 Jul 1

    ASJC Scopus subject areas

    • Microbiology (medical)
    • Infectious Diseases

    Fingerprint Dive into the research topics of 'Once daily versus every two week multidose ofloxacin in patients with acute exacerbations of chronic respiratory disease'. Together they form a unique fingerprint.

  • Cite this