On the role of mercury in the non-covalent stabilisation of consecutive U-HgII-U metal-mediated nucleic acid base pairs: Metallophilic attraction enters the world of nucleic acids

Ladislav Benda, Michal Straka, Yoshiyuki Tanaka, Vladimír Sychrovský

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Metal atoms with a closed-shell electronic structure and positive charge as for example the AuI, PtII, AgI, TlI or HgII atoms do not in some compounds repel each other due to the so-called metallophilic attraction (P. Pyykkö, Chem. Rev., 1997, 97, 597-636). Here we highlight the role of the HgII⋯Hg II metallophilic attraction between the consecutive metal-mediated mismatched base pairs of nucleic acids. Usually, the base stacking dominates the non-covalent interactions between steps of native nucleic acids. In the presence of metal-mediated base pairs these non-covalent interactions are enriched by the metal-base interactions and the metallophilic attraction. The two interactions arising due to the metal linkage of the mismatches were found in this study to have a stabilizing effect on nucleic acid structure. The calculated data are consistent with recent experimental observations. The stabilization due to the metallophilic attraction seems to be a generally important concept for the nucleic acids containing heavy metals with short contacts.

Original languageEnglish
Pages (from-to)100-103
Number of pages4
JournalPhysical Chemistry Chemical Physics
Volume13
Issue number1
DOIs
Publication statusPublished - 2011 Jan 7

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry

Fingerprint Dive into the research topics of 'On the role of mercury in the non-covalent stabilisation of consecutive U-Hg<sup>II</sup>-U metal-mediated nucleic acid base pairs: Metallophilic attraction enters the world of nucleic acids'. Together they form a unique fingerprint.

Cite this