TY - JOUR
T1 - On-line [11C]methylation using [11C]methyl iodide for the automated preparation of 11C-radiopharmaceuticals
AU - Iwata, Ren
AU - Pascali, Claudio
AU - Yuasa, Mitsuaki
AU - Yanai, Kazuhiko
AU - Takahashi, Toshihiro
AU - Ido, Tatsuo
PY - 1992/9
Y1 - 1992/9
N2 - A novel method for the efficient preparation of 11C-radiopharmaceuticals by on-line [11C]methylation using [11C]methyl iodide has been developed and applied to a rapid, convenient automated system. [11C]Methyl iodide is first trapped in a short column, containing an adsorber and coated substrate, which is connected to an HPLC injector. DMF is then introduced. Alternatively the substrate is added with the DMF. A whole reaction mixture can be easily injected onto an HPLC column for purification by switching the injector valve immediately after the reaction. Thus, radiochemical yields in the preparation of 11C-labeled doxepin, benztropine, cyproheptadine and N-methylspiperone have been improved remarkably and the synthetic procedure simplified.
AB - A novel method for the efficient preparation of 11C-radiopharmaceuticals by on-line [11C]methylation using [11C]methyl iodide has been developed and applied to a rapid, convenient automated system. [11C]Methyl iodide is first trapped in a short column, containing an adsorber and coated substrate, which is connected to an HPLC injector. DMF is then introduced. Alternatively the substrate is added with the DMF. A whole reaction mixture can be easily injected onto an HPLC column for purification by switching the injector valve immediately after the reaction. Thus, radiochemical yields in the preparation of 11C-labeled doxepin, benztropine, cyproheptadine and N-methylspiperone have been improved remarkably and the synthetic procedure simplified.
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U2 - 10.1016/0883-2889(92)90048-J
DO - 10.1016/0883-2889(92)90048-J
M3 - Article
C2 - 1330987
AN - SCOPUS:0026720160
VL - 43
SP - 1083
EP - 1088
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
SN - 0969-8043
IS - 9
ER -