On-line [11C]methylation using [11C]methyl iodide for the automated preparation of 11C-radiopharmaceuticals

Ren Iwata; Claudio Pascali; Mitsuaki Yuasa; Kazuhiko Yanai; Toshihiro Takahashi; Tatsuo Ido

doi:10.1016/0883-2889(92)90048-J

On-line [¹¹C]methylation using [¹¹C]methyl iodide for the automated preparation of ¹¹C-radiopharmaceuticals

Ren Iwata, Claudio Pascali, Mitsuaki Yuasa, Kazuhiko Yanai, Toshihiro Takahashi, Tatsuo Ido

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

A novel method for the efficient preparation of ¹¹C-radiopharmaceuticals by on-line [¹¹C]methylation using [¹¹C]methyl iodide has been developed and applied to a rapid, convenient automated system. [¹¹C]Methyl iodide is first trapped in a short column, containing an adsorber and coated substrate, which is connected to an HPLC injector. DMF is then introduced. Alternatively the substrate is added with the DMF. A whole reaction mixture can be easily injected onto an HPLC column for purification by switching the injector valve immediately after the reaction. Thus, radiochemical yields in the preparation of ¹¹C-labeled doxepin, benztropine, cyproheptadine and N-methylspiperone have been improved remarkably and the synthetic procedure simplified.

Original language	English
Pages (from-to)	1083-1088
Number of pages	6
Journal	International Journal of Radiation Applications and Instrumentation. Part
Volume	43
Issue number	9
DOIs	https://doi.org/10.1016/0883-2889(92)90048-J
Publication status	Published - 1992 Sep

ASJC Scopus subject areas

Radiation
Engineering(all)

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On-line [¹¹C]methylation using [¹¹C]methyl iodide for the automated preparation of ¹¹C-radiopharmaceuticals. / Iwata, Ren; Pascali, Claudio; Yuasa, Mitsuaki; Yanai, Kazuhiko; Takahashi, Toshihiro; Ido, Tatsuo.

In: International Journal of Radiation Applications and Instrumentation. Part, Vol. 43, No. 9, 09.1992, p. 1083-1088.

Research output: Contribution to journal › Article › peer-review

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abstract = "A novel method for the efficient preparation of 11C-radiopharmaceuticals by on-line [11C]methylation using [11C]methyl iodide has been developed and applied to a rapid, convenient automated system. [11C]Methyl iodide is first trapped in a short column, containing an adsorber and coated substrate, which is connected to an HPLC injector. DMF is then introduced. Alternatively the substrate is added with the DMF. A whole reaction mixture can be easily injected onto an HPLC column for purification by switching the injector valve immediately after the reaction. Thus, radiochemical yields in the preparation of 11C-labeled doxepin, benztropine, cyproheptadine and N-methylspiperone have been improved remarkably and the synthetic procedure simplified.",

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AU - Takahashi, Toshihiro

AU - Ido, Tatsuo

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AB - A novel method for the efficient preparation of 11C-radiopharmaceuticals by on-line [11C]methylation using [11C]methyl iodide has been developed and applied to a rapid, convenient automated system. [11C]Methyl iodide is first trapped in a short column, containing an adsorber and coated substrate, which is connected to an HPLC injector. DMF is then introduced. Alternatively the substrate is added with the DMF. A whole reaction mixture can be easily injected onto an HPLC column for purification by switching the injector valve immediately after the reaction. Thus, radiochemical yields in the preparation of 11C-labeled doxepin, benztropine, cyproheptadine and N-methylspiperone have been improved remarkably and the synthetic procedure simplified.

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