On-line interconversion of [15O]O2 and [15O]CO2 via metal oxide by isotopic exchange

Ren Iwata, Tatsuo Ido, Yoshiki Fujisawa, Shigeki Yamazaki

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    8 Citations (Scopus)


    A novel method has been developed for the on-line production of 15O-labelled gases. The 15O exchange reactions between O2 and CO2 assisted by a metal oxide catalyst were successfully applied to on-line interconversion of [15O]O2 and [15O]CO2 with Hopcalite II(CuO 40% and MnO2 60%). The conversion reactions were optimized as to the reaction temperature, the amount of the catalyst, and the flow rate of a gas added for oxygen exchange. [15O]O2 was converted to [15O]CO2 in a 80% yield with 0.7 g of Hopcalite II and 100 mL/min of CO2 at 500°C, and [15O]CO2 to [15O]O2 in 70% with 100 mL/min of O2 at 650°C. The radiochemical purities of the 15O-labelled gases converted under the optimal conditions were high enough for clinical studies using the standard dilution and inhalation procedures.

    Original languageEnglish
    Pages (from-to)1207-1211
    Number of pages5
    JournalInternational Journal of Radiation Applications and Instrumentation. Part
    Issue number12
    Publication statusPublished - 1988

    ASJC Scopus subject areas

    • Radiation
    • Engineering(all)


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