Omission of serial arterial blood sampling for quantitative analysis of monkey PET data using independent component analysis-based method

Mika Naganawa, Hideo Tsukada, Hiroyuki Ohba, Kiichi Ishiwata, Chie Seki, Miho Shidahara, Yuichi Kimura

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Serial arterial blood sampling is required to measure a blood input function in quantitative estimation of physiological parameters in dynamic positron emission tomography (PET) studies. However, blood sampling is problematic for animal PET study due to limited amount of blood allowed. Therefore, it is of interest to obviate arterial blood sampling. We have previously proposed a method for estimating a blood input curve based on independent component analysis in human study. In this paper, we applied the method to monkey [18F]fluorodeoxyglucose studies, and validated its applicability by comparing the estimated regional cerebral metabolic rates of glucose using the estimated and the measured blood input function. Experimental results suggest that the proposed method enables quantitative analysis in PET without serial arterial blood sampling not only in human data but also in monkey data.

Original languageEnglish
Title of host publication2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC
Pages4510-4512
Number of pages3
DOIs
Publication statusPublished - 2007 Dec 1
Externally publishedYes
Event2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC - Honolulu, HI, United States
Duration: 2007 Oct 272007 Nov 3

Publication series

NameIEEE Nuclear Science Symposium Conference Record
Volume6
ISSN (Print)1095-7863

Other

Other2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC
CountryUnited States
CityHonolulu, HI
Period07/10/2707/11/3

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Omission of serial arterial blood sampling for quantitative analysis of monkey PET data using independent component analysis-based method'. Together they form a unique fingerprint.

Cite this