Omics research project on prospective cohort studies from the Tohoku Medical Megabank Project

Seizo Koshiba, Ikuko Motoike, Daisuke Saigusa, Jin Inoue, Matsuyuki Shirota, Yasutake Katoh, Fumiki Katsuoka, Inaho Danjoh, Atsushi Hozawa, Shinichi Kuriyama, Naoko Minegishi, Masao Nagasaki, Takako Takai-Igarashi, Soichi Ogishima, Nobuo Fuse, Shigeo Kure, Gen Tamiya, Osamu Tanabe, Jun Yasuda, Kengo KinoshitaMasayuki Yamamoto

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Population-based prospective cohort studies are indispensable for modern medical research as they provide important knowledge on the influences of many kinds of genetic and environmental factors on the cause of disease. Although traditional cohort studies are mainly conducted using questionnaires and physical examinations, modern cohort studies incorporate omics and genomic approaches to obtain comprehensive physical information, including genetic information. Here, we report the design and midterm results of multi-omics analysis on population-based prospective cohort studies from the Tohoku Medical Megabank (TMM) Project. We have incorporated genomic and metabolomic studies in the TMM cohort study as both metabolome and genome analyses are suitable for high-throughput analysis of large-scale cohort samples. Moreover, an association study between the metabolome and genome show that metabolites are an important intermediate phenotype connecting genetic and lifestyle factors to physical and pathologic phenotypes. We apply our metabolome and genome analyses to large-scale cohort samples in the following studies.

Original languageEnglish
Pages (from-to)406-417
Number of pages12
JournalGenes to Cells
Volume23
Issue number6
DOIs
Publication statusPublished - 2018 Jun

Keywords

  • Tohoku Medical Megabank
  • association study
  • cohort
  • jMorp
  • metabolome
  • omics
  • proteome

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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