Oligodeoxynucleotides expressing polyguanosine motifs promote antitumor activity through the upregulation of IL-2

Nobuaki Kobayashi, Choongman Hong, Dennis M. Klinman, Hidekazu Shirota

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The primary goal of cancer immunotherapy is to elicit an immune response capable of eliminating the tumor. One approach toward accomplishing that goal uses general (rather than tumor-specific) immunomodulatory agents to boost the number and activity of pre-existing CTLs. We find that the intratumoral injection of polyguanosine (poly-G) oligonucleotides (ODN) has such an effect, boosting antitumor immunity and promoting tumor regression. The antitumor activity of poly-G ODN was mediated through CD8 T cells in a TLR9-independent manner. Mechanistically, poly-G ODN directly induced the phosphorylation of Lck (an essential element of the T cell-signaling pathway), thereby enhancing the production of IL-2 and CD8 T cell proliferation. These findings establish poly-G ODN as a novel type of cancer immunotherapy.

Original languageEnglish
Pages (from-to)1882-1889
Number of pages8
JournalJournal of Immunology
Volume190
Issue number4
DOIs
Publication statusPublished - 2013 Feb 15

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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