TY - JOUR
T1 - Oligoclonal IgG bands in Japanese patients with multiple sclerosis. A comparative study between isoelectric focusing with IgG immunofixation and high-resolution agarose gel electrophoresis
AU - Nakashima, Ichiro
AU - Fujihara, Kazuo
AU - Sato, Shigeru
AU - Itoyama, Yasuto
N1 - Funding Information:
Authors thank Mr. Brent Bell for reading the manuscript. This work was supported by the grants-in-aid for General Scientific Research of the Ministry of Education, Science, Sports, Culture and Technology of Japan.
PY - 2005/2
Y1 - 2005/2
N2 - A low prevalence of oligoclonal IgG bands (OB) has been reported as a unique feature of Japanese multiple sclerosis (MS) as compared with Western MS. We compared the frequency of OB between isoelectric focusing (IEF) and agarose gel electrophoresis (AGE) in 59 Japanese patients with clinically definite MS [39 with conventional form of MS (CMS) and 20 with optic-spinal form of MS (OSMS)]. The frequency of IEF-OB in total MS was 54%, whereas that of AGE-OB was only 17%. When OSMS was excluded, the frequency increased to 77% by IEF, whereas it remained 23% by AGE. Our study strongly suggests that IEF is highly effective for detecting OB in Japanese MS patients.
AB - A low prevalence of oligoclonal IgG bands (OB) has been reported as a unique feature of Japanese multiple sclerosis (MS) as compared with Western MS. We compared the frequency of OB between isoelectric focusing (IEF) and agarose gel electrophoresis (AGE) in 59 Japanese patients with clinically definite MS [39 with conventional form of MS (CMS) and 20 with optic-spinal form of MS (OSMS)]. The frequency of IEF-OB in total MS was 54%, whereas that of AGE-OB was only 17%. When OSMS was excluded, the frequency increased to 77% by IEF, whereas it remained 23% by AGE. Our study strongly suggests that IEF is highly effective for detecting OB in Japanese MS patients.
KW - Agarose gel electrophoresis
KW - Isoelectric focusing
KW - Multiple sclerosis
KW - Neuromyelitis optica
KW - Oligoclonal IgG bands
KW - Optic-spinal form of multiple sclerosis
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U2 - 10.1016/j.jneuroim.2004.09.011
DO - 10.1016/j.jneuroim.2004.09.011
M3 - Article
C2 - 15652412
AN - SCOPUS:12344331799
VL - 159
SP - 133
EP - 136
JO - Advances in Neuroimmunology
JF - Advances in Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -