Octreotide in control of multiple liver metastases from gastrinoma

Fumito Saijo, Hiroo Naito, Yuji Funayama, Kouchei Fukushima, Chikashi Shibata, Akihiko Hashimoto, Taku Kitayama, Munenori Nagao, Seiki Matsuno, Iwao Sasaki

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

The somatostatin analogue octreotide was effective in controlling systemic effects related to multiple liver metastases from a gastrinoma. A 61-year-old man underwent distal gastrectomy for gastrinoma in the duodenum, because a curative resection was not feasible due to metastases found in paraaortic lymph nodes during operation. Multiple liver metastases, associated with an increase in serum gastrin concentration, were found by magnetic resonance imaging 16 months after the operation. Although chemotherapy with dimethyltrizenoimidazole carboxamide was not effective, subcutaneous administration of octreotide was effective in controlling the growth of the liver metastases and in stabilizing serum gastrin. The patient now receives subcutaneous injections of octreotide, at 200 μg a day, twice a week, as an outpatient.

Original languageEnglish
Pages (from-to)905-908
Number of pages4
JournalJournal of gastroenterology
Volume38
Issue number9
DOIs
Publication statusPublished - 2003 Sep

Keywords

  • Gastrinoma
  • Multiple liver metastases
  • Octreotide

ASJC Scopus subject areas

  • Gastroenterology

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