Occurrence of orally administered curcuminoid as glucuronide and glucuronide/sulfate conjugates in rat plasma

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221 Citations (Scopus)

Abstract

Curcuminoids, curcumin and its structurally related compounds, constitute the phenolic yellowish pigment of turmeric. We investigated the absorption and metabolism of orally administered curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) in rats. HPLC and LC-MS analyses after enzymatic hydrolyses showed that the predominant metabolites in plasma following administration were glucuronides and glucuronide/sulfates (conjugates with both glucuronide and sulfate) of curcuminoids. The plasma concentrations of conjugated curcuminoids reached a maximum one hour after administration. The conjugative enzyme activities for glucuronidation and sulfation of curcumin were found in liver, kidney and intestinal mucosa. These results indicate that orally administered curcuminoids are absorbed from the alimentary tract and present in the general blood circulation after largely being metabolized to the form of glucuronide and glucuronide/sulfate conjugates. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)2785-2793
Number of pages9
JournalLife Sciences
Volume67
Issue number23
DOIs
Publication statusPublished - 2000 Oct 27

Keywords

  • Absorption
  • Conjugation
  • Curcumin
  • Curcuminoid
  • Plasma
  • Rat

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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