Occurrence of free D-aspartic acid in marine macroalgae

E. Nagahisa, N. Kanno, M. Sato, Y. Sato

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


The biologically rare D-aspartic acid was found in extracts of marine macroalgae. DL-aspartic acid was isolated from the Phaeophyta, Hizikia fusiformis, by ion-exchange chromatography, and crystallized from aqueous ethanol. It was characterized by optical-rotatory-dispersion analysis and reversed-phase HPLC analysis. The crystal consisted of equal amounts of D and L isomers. The presence of free D-aspartic acid was verified in 15 species from among 20 species of marine macroalgae by the same method (HPLC). Generally, Phaeophyta contained a high concentration of D-aspartic acid in contrast with the low concentration in Phycophyta and Rhodophyta. Particularly in Costaria costata, Hizikia fusiformis and Sargassum yezoensis, belonging to Phaeophyta, D-aspartic acid was found in concentrations proportional to those of L-aspartic acid.

Original languageEnglish
Pages (from-to)11-19
Number of pages9
JournalBiochemistry International
Issue number1
Publication statusPublished - 1992 Jan 1

ASJC Scopus subject areas

  • Biochemistry


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