The chiral lanthanide shift reagent, tris[3- (trifluoromethylhydroxymethylene)-(+)-camphorato]samarium(III) [Sm(tfc) 3], was shown to resolve the 1H NMR signals of the enantiomers of α-amino esters without causing serious line broadening. This distinctive feature of Sm(tfc) 3 made it possible to examine the enantiomeric chemical shift non-equivalence of several protons in ester substrates, increasing the reliability of the empirical assignment of the absolute configuration as compared to earlier techniques.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry