Observation of transformation behavior of octacalcium phosphate to hydroxyapatite

Natsuko Ito, Masanobu Kamitakahara, Koji Ioku

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Octacalcium phosphate (OCP) is regarded as a precursor of hydroxyapatite (HA) which is a main inorganic comstituent of human bones and teeth. OCP is becoming regarded as an important biomaterial. Recently, implanted OCP was found to be converted to apatitic phase in the body and support bone regeneration. Therefore, it is important to reveal the transformation mechanism of OCP to HA for revealing the mechanism of bone formation and for the development of biomedical materials for bone. In this study, we focused on the dissolution of OCP and precipitation of HA. OCP particles were immersed in distilled water at 60 ?C. The temporal change of the immersed powders and immersing solution were examined, and the transformation mechanism of OCP to HA was discussed. As there was an unreactive period in the first stage of the transformation, HA crystals seemed to grow easily once HA nuclei were formed. It is speculated that HA nuclei formed on OCP crystals by heterogeneous nucleation, and then HA crystals grow using calcium and phosphoric ions supplied from dissolved OCP.

Original languageEnglish
Title of host publicationBioceramics 24
PublisherTrans Tech Publications Ltd
Pages11-14
Number of pages4
Edition1
ISBN (Print)9783037855171
DOIs
Publication statusPublished - 2013 Jan 1
Event24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012 - Fukuoka, Japan
Duration: 2012 Oct 212012 Oct 24

Publication series

NameKey Engineering Materials
Number1
Volume529-530
ISSN (Print)1013-9826
ISSN (Electronic)1662-9795

Other

Other24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012
CountryJapan
CityFukuoka
Period12/10/2112/10/24

Keywords

  • Hydroxyapatite
  • Octacalcium phosphate
  • Transformation

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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