Observation of in Vitro Activities and clinical Evaluation Infection on KW-1062

Akira Watanabe; Masako Sasaki; Yukinori Yonemoto; Sonoko Saito; Kotaro Oizumi; Kiyoshi Konno

doi:10.11250/chemotherapy1953.25.1934

Observation of in Vitro Activities and clinical Evaluation Infection on KW-1062

Akira Watanabe, Masako Sasaki, Yukinori Yonemoto, Sonoko Saito, Kotaro Oizumi, Kiyoshi Konno

Research output: Contribution to journal › Article › peer-review

Abstract

In vitro antimicrobial activity and therapeutic effects of KW-1062 on respiratory tract infections were evaluated and the following results were obtained. The MICs of the drug against clinical isolates of Klebsiella pneumoniae were slightly lower than those of DKB and nearly the same as those of GM. The drug was revealed to be less effective than GM or DKB against Pseudomonas aeruginosa. Of 4 cases, treated with the drug, of respiratory tract infections with gram negative bacilli, an excellent bacteriological and clinical effect was observed in one case, but the 3 remaining cases showed negative clinical responses during the periods of the administration of the drug.

Original language	English
Pages (from-to)	1934-1938
Number of pages	5
Journal	Chemotherapy
Volume	25
Issue number	7
DOIs	https://doi.org/10.11250/chemotherapy1953.25.1934
Publication status	Published - 1977 Jan 1

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology
Drug Discovery
Oncology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.11250/chemotherapy1953.25.1934

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abstract = "In vitro antimicrobial activity and therapeutic effects of KW-1062 on respiratory tract infections were evaluated and the following results were obtained. The MICs of the drug against clinical isolates of Klebsiella pneumoniae were slightly lower than those of DKB and nearly the same as those of GM. The drug was revealed to be less effective than GM or DKB against Pseudomonas aeruginosa. Of 4 cases, treated with the drug, of respiratory tract infections with gram negative bacilli, an excellent bacteriological and clinical effect was observed in one case, but the 3 remaining cases showed negative clinical responses during the periods of the administration of the drug.",

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AU - Konno, Kiyoshi

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AB - In vitro antimicrobial activity and therapeutic effects of KW-1062 on respiratory tract infections were evaluated and the following results were obtained. The MICs of the drug against clinical isolates of Klebsiella pneumoniae were slightly lower than those of DKB and nearly the same as those of GM. The drug was revealed to be less effective than GM or DKB against Pseudomonas aeruginosa. Of 4 cases, treated with the drug, of respiratory tract infections with gram negative bacilli, an excellent bacteriological and clinical effect was observed in one case, but the 3 remaining cases showed negative clinical responses during the periods of the administration of the drug.

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Observation of in Vitro Activities and clinical Evaluation Infection on KW-1062

Abstract

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