TY - JOUR
T1 - O-nitroso aldol synthesis
T2 - Catalytic enantioselective route to α-aminooxy carbonyl compounds via enamine intermediate
AU - Momiyama, Norie
AU - Torii, Hiromi
AU - Saito, Susumu
AU - Yamamoto, Hisashi
PY - 2004/4/13
Y1 - 2004/4/13
N2 - The approach using pyrrolidine enamine as substrate has been studied for this synthesis, and an important catalyst structural feature has been developed. After survey of pyrrolidine-based Brønsted acid catalyst, tetrazole catalyst (3f) was found to be optimal in synthesis of aminooxy carbonyl compounds in high yields, with complete enantioselectivity not only for aldehydes but also for ketones.
AB - The approach using pyrrolidine enamine as substrate has been studied for this synthesis, and an important catalyst structural feature has been developed. After survey of pyrrolidine-based Brønsted acid catalyst, tetrazole catalyst (3f) was found to be optimal in synthesis of aminooxy carbonyl compounds in high yields, with complete enantioselectivity not only for aldehydes but also for ketones.
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U2 - 10.1073/pnas.0307785101
DO - 10.1073/pnas.0307785101
M3 - Article
C2 - 15067138
AN - SCOPUS:1842732184
VL - 101
SP - 5374
EP - 5378
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 15
ER -