Nucleotide Sequence of the Putative Human Tyrosinase Pseudogene

Atsushi Takeda, Shigeki Shibahara, Jun Matsunaga, Yasushi Tomita, Hachiro Tagami

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

We have cloned and sequenced the putative human tyrosinase pseudogene, which shares more than 98% nucleotide homology with exon 4 and exon 5 of the human tyrosinase gene including their flanking introns. Because of such a high homology, both the tyrosinase gene and its pseudogene could be amplified from genomic DNA by polymerase chain reaction. The nucleotide sequences presented thus enable us to discriminate the tyrosinase gene from its related sequences and are invaluable for a gene diagnosis of oculocutaneous albinism.

Original languageEnglish
Pages (from-to)295-297
Number of pages3
JournalTohoku Journal of Experimental Medicine
Volume163
Issue number4
DOIs
Publication statusPublished - 1991

Keywords

  • chromosome 11
  • gene diagnosis
  • inherited disease
  • melanin pigments
  • oculocutaneous albinism

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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