Nucleotide sequence of a nearly full‐length cDNA coding for pepsinogen of rat gastric mucosa

Yoshikazu ICHIHARA, Kazuhiro SOGAWA, Ken‐ichirou ‐i MOROHASHI, Yoshiaki FUJI‐KURIYAMA, Kenji TAKAHASHI

    Research output: Contribution to journalArticle

    45 Citations (Scopus)

    Abstract

    A nearly full‐length rat pepsinogen cDNA was isolated from a rat gastric mucosa cDNA library and its nucleotide sequence was determined. The cDNA comprises 1370 base pairs (bp), including the 5′‐non‐coding region (60 bp), the coding nucleotide sequence (1176 bp) and the 3′‐non‐coding region (131 bp). The predicted amino acid sequence of rat prepepsinogen (392 residues) contains a 16‐residue signal sequence followed by the pepsionogen moiety of 376 residues. Rat pepsinogen has an amino acid composition characteristic of C‐type pepsinogens and is much more homologous in amino acid sequence with C‐type pepsinogens than A‐type pepsinogens. These results indicate that the major form of rat pepsinogen can be classified as a C type pepsinogen.

    Original languageEnglish
    Pages (from-to)7-12
    Number of pages6
    JournalEuropean Journal of Biochemistry
    Volume161
    Issue number1
    DOIs
    Publication statusPublished - 1986 Nov

    ASJC Scopus subject areas

    • Biochemistry

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