Nucleotide sequence divergence and functional constraint in VIP precursor mRNA evolution between human and rat

Mikio Nishizawa, Yumiko Hayakawa, Noboru Yanaihara, Hiroshi Okamoto

Research output: Contribution to journalArticlepeer-review

194 Citations (Scopus)

Abstract

The nucleotide sequence analysis of cloned cDNA for VIP precursor from rat cerebral cortex reveals that the precursor contains both rat VIP and PHI-27. The deduced primary structure of rat VIP is identical with human VIP. The amino acid sequence of rat PHI-27 differs by 4 amino acids from human PHM-27. When each VIP precursor is divided functionally into 6 domains, the amino acid sequence homology between rat and human precursors ranges from 69 to 100%. In contrast, any domain exhibits an essentially equal degree of nucleotide sequence homology. Rat VIP Rat PHI-27 VIP precursor VIP precursor mRNA Human PHM-27 Sequence homology.

Original languageEnglish
Pages (from-to)55-59
Number of pages5
JournalFEBS Letters
Volume183
Issue number1
DOIs
Publication statusPublished - 1985 Apr 8

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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