TY - JOUR
T1 - Nucleotide sequence divergence and functional constraint in VIP precursor mRNA evolution between human and rat
AU - Nishizawa, Mikio
AU - Hayakawa, Yumiko
AU - Yanaihara, Noboru
AU - Okamoto, Hiroshi
N1 - Funding Information:
This work was supportedi n part by Grants-in-Aid for Scientific Research and for Cancer Researchf rom the Ministry of Education, Science and Culture, Japan.
PY - 1985/4/8
Y1 - 1985/4/8
N2 - The nucleotide sequence analysis of cloned cDNA for VIP precursor from rat cerebral cortex reveals that the precursor contains both rat VIP and PHI-27. The deduced primary structure of rat VIP is identical with human VIP. The amino acid sequence of rat PHI-27 differs by 4 amino acids from human PHM-27. When each VIP precursor is divided functionally into 6 domains, the amino acid sequence homology between rat and human precursors ranges from 69 to 100%. In contrast, any domain exhibits an essentially equal degree of nucleotide sequence homology. Rat VIP Rat PHI-27 VIP precursor VIP precursor mRNA Human PHM-27 Sequence homology.
AB - The nucleotide sequence analysis of cloned cDNA for VIP precursor from rat cerebral cortex reveals that the precursor contains both rat VIP and PHI-27. The deduced primary structure of rat VIP is identical with human VIP. The amino acid sequence of rat PHI-27 differs by 4 amino acids from human PHM-27. When each VIP precursor is divided functionally into 6 domains, the amino acid sequence homology between rat and human precursors ranges from 69 to 100%. In contrast, any domain exhibits an essentially equal degree of nucleotide sequence homology. Rat VIP Rat PHI-27 VIP precursor VIP precursor mRNA Human PHM-27 Sequence homology.
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U2 - 10.1016/0014-5793(85)80953-4
DO - 10.1016/0014-5793(85)80953-4
M3 - Article
C2 - 3838518
AN - SCOPUS:0021921889
VL - 183
SP - 55
EP - 59
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 1
ER -