Nucleotide sequence determination of chicken glucagon precursor cDNA. Chicken preproglucagon does not contain glucagon-like peptide II

Shin Hasegawa, Kimio Terazono, Koji Nata, Tatsuyuki Takada, Hiroshi Yamamoto, Hiroshi Okamoto

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

cDNA clones coding for glucagon were isolated from a chicken pancreas cDNA library, and the nucleotide and amino acid sequences were determined. The amino acid sequence of chicken glucagon was HSQGTFTSDYSKYLDSRRAQDFVQWLMST, which was contained in the 151-amino acid long precursor, being preceded by a signal sequence and an amino-terminal peptide (NH2-peptide) and followed by an intervening peptide and a glucagon-like peptide I (GLP-I). Chicken preproglucagon, however, lacked GLP-II and intervening peptide II which have been shown to be contained in mammalian glucagon precursors.

Original languageEnglish
Pages (from-to)117-120
Number of pages4
JournalFEBS Letters
Volume264
Issue number1
DOIs
Publication statusPublished - 1990 May 7

Keywords

  • Gallus gallus domesticus
  • Glucagon
  • Glucagon-like peptide
  • Preproglucagon
  • cDNA cloning
  • mRNA

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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