Abstract
cDNA clones coding for glucagon were isolated from a chicken pancreas cDNA library, and the nucleotide and amino acid sequences were determined. The amino acid sequence of chicken glucagon was HSQGTFTSDYSKYLDSRRAQDFVQWLMST, which was contained in the 151-amino acid long precursor, being preceded by a signal sequence and an amino-terminal peptide (NH2-peptide) and followed by an intervening peptide and a glucagon-like peptide I (GLP-I). Chicken preproglucagon, however, lacked GLP-II and intervening peptide II which have been shown to be contained in mammalian glucagon precursors.
Original language | English |
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Pages (from-to) | 117-120 |
Number of pages | 4 |
Journal | FEBS Letters |
Volume | 264 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1990 May 7 |
Keywords
- Gallus gallus domesticus
- Glucagon
- Glucagon-like peptide
- Preproglucagon
- cDNA cloning
- mRNA
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology