We molecularly characterized the second gene, c‐yes‐2, of two copies of yes‐related genes which we previously found to contain in the human genome. First, nucleotide sequence analysis revealed that the c‐yes‐2 gene is a pseudogene of the c‐yes‐1 gene. Second, by using two independent methods, hybridization of both DNAs from sorted chromosomes and metaphase spreads with c‐yes‐2 DNA, we assigned the c‐yes‐2 gene to chromosome 22q11.2. This chromosomal localization is inconsistent with that given in our previous report. The failure of proper mapping in our experiment might have been caused by instability of hybrid cell clones.
|Number of pages||8|
|Journal||Japanese Journal of Cancer Research|
|Publication status||Published - 1988 Jun|
- Chromosome 22
ASJC Scopus subject areas
- Cancer Research