TY - JOUR
T1 - Nucleotide Sequence and Chromosomal Mapping of the Human c‐yes‐2 Gene
AU - Semba, Kentaro
AU - Nishizawa, Makoto
AU - Satoh, Hitoshi
AU - Fukushige, Shin‐ichi ‐i
AU - Yoshida, Michihiro C.
AU - Sasaki, Motomichi
AU - Marsusbra, Ken‐ichi ‐i
AU - Yamamoto, Tadashi
AU - Toyoshima, Kumao
PY - 1988/6
Y1 - 1988/6
N2 - We molecularly characterized the second gene, c‐yes‐2, of two copies of yes‐related genes which we previously found to contain in the human genome. First, nucleotide sequence analysis revealed that the c‐yes‐2 gene is a pseudogene of the c‐yes‐1 gene. Second, by using two independent methods, hybridization of both DNAs from sorted chromosomes and metaphase spreads with c‐yes‐2 DNA, we assigned the c‐yes‐2 gene to chromosome 22q11.2. This chromosomal localization is inconsistent with that given in our previous report. The failure of proper mapping in our experiment might have been caused by instability of hybrid cell clones.
AB - We molecularly characterized the second gene, c‐yes‐2, of two copies of yes‐related genes which we previously found to contain in the human genome. First, nucleotide sequence analysis revealed that the c‐yes‐2 gene is a pseudogene of the c‐yes‐1 gene. Second, by using two independent methods, hybridization of both DNAs from sorted chromosomes and metaphase spreads with c‐yes‐2 DNA, we assigned the c‐yes‐2 gene to chromosome 22q11.2. This chromosomal localization is inconsistent with that given in our previous report. The failure of proper mapping in our experiment might have been caused by instability of hybrid cell clones.
KW - Chromosome 22
KW - Pseudogene
KW - c‐yes‐2
UR - http://www.scopus.com/inward/record.url?scp=0023705391&partnerID=8YFLogxK
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U2 - 10.1111/j.1349-7006.1988.tb02227.x
DO - 10.1111/j.1349-7006.1988.tb02227.x
M3 - Article
C2 - 3137198
AN - SCOPUS:0023705391
VL - 79
SP - 710
EP - 717
JO - Cancer Science
JF - Cancer Science
SN - 1347-9032
IS - 6
ER -
