Nucleosomal arrays reconstituted from ring and linear DNA

Sumiko Araki, Kohji Hizume, Takafumi Iwaki, Yuki Suzuki, Kunio Takeyasu, Kenichi Yoshikawa

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


The effect of DNA architecture on reconstituted nucleosomal arrays is examined for both linear and fully relaxed circular DNA (ring DNA). We performed experimental observation with AFM, and found that ring DNA was more efficient at forming nucleosomes than linear DNA. Based on a consideration of free energy, we suggest that short-range steric interaction between nucleosomes stabilizes the formation of nucleosomes, and that the ring architecture facilitates the formation of nucleosomes by increasing contacts between nucleosomes, through shrinking of the monomolecular DNA chain conformation.

Original languageEnglish
Pages (from-to)284-289
Number of pages6
JournalChemical Physics Letters
Issue number4-6
Publication statusPublished - 2009 Sep 17
Externally publishedYes

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry


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