Nucleoskeleton proteins for nuclear dynamics

Kei Miyamoto, Masahiko Harata

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    The eukaryotic nucleus shows organized structures of chromosomes, transcriptional components and their associated proteins. It has been believed that such a dense nuclear environment prevents the formation of a cytoskeleton-like network of protein filaments. However, accumulating evidence suggests that the cell nucleus also possesses structural filamentous components to support nuclear organization and compartments, which are referred to as nucleoskeleton proteins. Nucleoskeleton proteins including lamins and actin influence nuclear dynamics including transcriptional regulation, chromatin organization and DNA damage responses. Furthermore, these nucleoskeleton proteins play a pivotal role in cellular differentiation and animal development. In this commentary, we discuss how nucleoskeleton-based regulatory mechanisms orchestrate nuclear dynamics.

    Original languageEnglish
    Pages (from-to)237-241
    Number of pages5
    JournalJournal of biochemistry
    Volume169
    Issue number3
    DOIs
    Publication statusPublished - 2021 Apr 18

    Keywords

    • lamin
    • nuclear actin
    • nuclear dynamics
    • nucleoskeleton

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology

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