Nucleation rate enhancement of porcine insulin by application of an external AC electric field

H. Koizumi, Y. Tomita, S. Uda, K. Fujiwara, J. Nozawa

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

The nucleation rate of porcine insulin increased under application of an external AC electric field at 3 MHz. This is attributed to the electrostatic energy added to the chemical potentials of both the liquid and solid phases; the chemical potential of the solid was significantly changed compared with that of the liquid, which lead to an increase in the driving force for nucleation. Therefore, application of an external AC electric field can be a useful technique for protein crystallization.

Original languageEnglish
Pages (from-to)155-157
Number of pages3
JournalJournal of Crystal Growth
Volume352
Issue number1
DOIs
Publication statusPublished - 2012 Aug 1

Keywords

  • A1. Biocrystallization
  • A1. Electric fields
  • A1. Nucleation
  • A2. Growth from solutions
  • B1. Proteins

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Inorganic Chemistry
  • Materials Chemistry

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