Nuclear deviation in hepatic parenchymal cells on sinusoidal surfaces in arctic animals

Mitsuru Sato, Mitsutaka Miura, Naosuke Kojima, Nobuyo Higashi, Katsuyuki Imai, Takeya Sato, Heidi L. Wold, Jan Øivind Moskaug, Rune Blomhoff, Kenjiro Wake, Nobert Roos, Trond Berg, Kaare R. Norum, Haruki Senoo

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

In normal rat and human, most of the nuclei of hepatic parenchymal cells are centrally located in the cytoplasm. However, it is reported that the nuclei of hepatic parenchymal cells are situated at a deviated position on sinusoidal surfaces under pathological situations such as chronic hepatitis, hepatocellular carcinoma, adenomatous hyperplasia, or regeneration. During a study on the mechanism of extreme vitamin A-accumulation in hepatic stellate cells of arctic animals including polar bears, arctic foxes, bearded seals, and glaucous gulls, we noticed that these arctic animals displayed the nuclear deviation in hepatic parenchymal cells on sinusoidal surfaces. In this study, we assessed the frequency of hepatic parenchymal cells showing the nuclear deviation on the sinusoidal surfaces in arctic animals. A significantly higher frequency of the nuclear deviation in hepatic parenchymal cells was seen in polar bears (89.8±3.4%), arctic foxes (68.6±10.5%), bearded seals (63.6±8.4%), and glaucous gulls (24.2±5.8%), as compared to that of control rat liver (9.8±3.5%). However, no pathological abnormality such as fibrosis or necrosis was observed in hepatic parenchymal and nonparenchymal cells of arctic animals, and there were no differences in the intralobular distribution of parenchymal cells displaying the nuclear deviation in the livers from either arctic animals and control rats. The hepatic sinusoidal littoral cells such as stellate cells or extracellular matrix components in the perisinusoidal spaces may influence the nuclear positioning and hence the polarity and intrinsic physiological function of parenchymal cells.

Original languageEnglish
Pages (from-to)71-77
Number of pages7
JournalCell structure and function
Volume26
Issue number2
DOIs
Publication statusPublished - 2001
Externally publishedYes

Keywords

  • Arctic fox
  • Hepatic parenchymal cell
  • Hepatic sinusoid
  • Nuclear positioning
  • Polar bear

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'Nuclear deviation in hepatic parenchymal cells on sinusoidal surfaces in arctic animals'. Together they form a unique fingerprint.

Cite this