Nuclear actin activates human transcription factor genes including the OCT4 Gene

Shota Yamazaki, Koji Yamamoto, Makio Tokunaga, Kumiko Sakata-Sogawa, Masahiko Harata

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    RNA microarray analyses revealed that nuclear actin activated many human transcription factor genes including OCT4, which is required for gene reprogramming. Oct4 is known to be activated by nuclear actin in Xenopus oocytes. Our findings imply that this process of OCT4 activation is conserved in vertebrates and among cell types and could be used for gene reprogramming of human cells.

    Original languageEnglish
    Pages (from-to)242-246
    Number of pages5
    JournalBioscience, Biotechnology and Biochemistry
    Volume79
    Issue number2
    DOIs
    Publication statusPublished - 2015

    Keywords

    • Nuclear actin
    • OCT4
    • Transcription
    • Transcription microarray

    ASJC Scopus subject areas

    • Biotechnology
    • Analytical Chemistry
    • Biochemistry
    • Applied Microbiology and Biotechnology
    • Molecular Biology
    • Organic Chemistry

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