Nuclear actin activates human transcription factor genes including the OCT4 Gene

Shota Yamazaki, Koji Yamamoto, Makio Tokunaga, Kumiko Sakata-Sogawa, Masahiko Harata

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

RNA microarray analyses revealed that nuclear actin activated many human transcription factor genes including OCT4, which is required for gene reprogramming. Oct4 is known to be activated by nuclear actin in Xenopus oocytes. Our findings imply that this process of OCT4 activation is conserved in vertebrates and among cell types and could be used for gene reprogramming of human cells.

Original languageEnglish
Pages (from-to)242-246
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume79
Issue number2
DOIs
Publication statusPublished - 2015 Jan 1

Keywords

  • Nuclear actin
  • OCT4
  • Transcription
  • Transcription microarray

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biotechnology
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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