N1-methyladenosine (m1A) RNA modification: The key to ribosome control

Hiroki Shima, Kazuhiko Igarashi

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

RNA displays diverse functions in living cells. The presence of various chemical modifications of RNA mediated by enzymes is one of the factors that impart such functional diversity to RNA. Among more than 100 types of RNA modification, N1-methyladenosine (m1A) is found mainly in tRNA and rRNA of many living organisms and is known to be deeply implicated in the topology or function of the two classes of RNA. In this commentary article, we would like to deal with the functional significance of m1A in RNA, and also to describe one methyltransferase installing m1A in a large subunit rRNA, whose orthologue in Caenorhabditis elegans was discovered recently and was reported in this journal.

Original languageEnglish
Pages (from-to)535-539
Number of pages5
JournalJournal of biochemistry
Volume167
Issue number6
DOIs
Publication statusPublished - 2020 Jun 1

Keywords

  • MA
  • Methyltransferase
  • Ribosome
  • Rrna

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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