Novel trichothecanes, paecilomycine A, B, and C, isolated from entomopathogenic fungus, Paecilomyces tenuipes

Haruhisa Kikuchi, Yasuhiro Miyagawa, Yuko Sahashi, Satoshi Inatomi, Asami Haganuma, Norimichi Nakahata, Yoshiteru Oshima

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Paecilomycine A (1), B (2), and C (3) were isolated from cultivated fruiting bodies of Paecilomyces tenuipes (Isaria japonica), which is a popular entomopathogenic fungus used in folk medicine and health foods in China, Korea, and Japan. The structures of 1â€"3 were deduced from their spectroscopic data and their absolute configurations were elucidated by preparing their MPA esters. Compound 1 showed activity in the neurotrophic factor biosynthesis in glial cells.

Original languageEnglish
Pages (from-to)6225-6228
Number of pages4
JournalTetrahedron Letters
Volume45
Issue number33
DOIs
Publication statusPublished - 2004 Aug 9

Keywords

  • Glial cell
  • PC-12 cell
  • Paecilomyces tenuipes
  • Trichothecane

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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