Novel testis- and embryo-specific isoforms of the phosphofructokinase-1 muscle type gene

Satoru Yamada, Hiromu Nakajima, Michael R. Kuehn

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

We have identified novel transcriptional isoforms of the human and mouse genes encoding muscle type phosphofructokinase-1 (PFK-M). These isoforms are expressed specifically in the testis and in the mid-gestation embryo, and have been termed TE-PFK-M (testis- and embryo-specific PFK-M). The 5′UTR of TE-PFK-M is composed of three newly identified exons that lie much farther upstream of the PFK-M coding region than the previously characterized 5′UTR. In addition, this upstream region encodes a series of small polyadenylated transcripts, some of which share the same exons found in the 5′UTR of TE-PFK-M, and which may play some role in regulating TE-PFK-M expression. These findings indicate an even more complex level of control of PFK-M expression than previously thought.

Original languageEnglish
Pages (from-to)580-587
Number of pages8
JournalBiochemical and biophysical research communications
Volume316
Issue number2
DOIs
Publication statusPublished - 2004 Apr 2
Externally publishedYes

Keywords

  • 5 UTR
  • Embryo
  • Gene expression
  • PFK-M
  • Phosphofructokinase-1, muscle type
  • Testis

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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