Novel synthetic antimicrobial peptides effective against methicillin-resistant Staphylococcus aureus

J. Alvarez-Bravo, S. Kurata, S. Natori

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)

Abstract

Previously, we identified a core undecapeptide of sapecin B having antimicrobial activity. Based on the structure of this peptide, we systematically synthesized peptides consisting of terminal basic motifs and internal oligo-leucine sequences and examined their antimicrobial activities. Of these peptides, RLKLLLLLRLK-NH2 and KLKLLLLLKLK-NH2 were found to have potent microbicidal activity against Staphylococcus aureus, Escherichia coli, methicillin-resistant S. aureus and Candida albicans in liquid medium. We also synthesized the D-enantiomer of KLKLLLLLKLK-NH2. This enantiomer was resistant to tryptic digestion and persisted longer in the culture medium, showing greater antimicrobial activity than the original peptide.

Original languageEnglish
Pages (from-to)535-538
Number of pages4
JournalBiochemical Journal
Volume302
Issue number2
DOIs
Publication statusPublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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