Novel synthesis of yttrium phosphate microspheres for radioembolization of cancer

M. Kawashita; N. Matsui; Z. Li; T. Miyazaki

doi:10.1088/1757-899X/18/19/192003

Novel synthesis of yttrium phosphate microspheres for radioembolization of cancer

M. Kawashita, N. Matsui, Z. Li, T. Miyazaki

MEN - Biomedical Engineering

Research output: Contribution to journal › Conference article › peer-review

5 Citations (Scopus)

Abstract

Chemically durable microspheres containing yttrium and/or phosphorus are useful for intra-arterial radiotherapy. In the present study, we attempted to prepare yttrium phosphate (YPO₄) microspheres with high chemical durability as well as smooth surface and investigated their chemical durability in simulated body environment. YPO₄ microspheres with smooth surface around 25 μm were successfully obtained, when gelatin droplets containing YPO₄ precursor was cooled to be solidified in water-in-oil emulsion and then heat-treated at 1100°C. The chemical durability of the heat-treated microspheres in simulated body fluid at pH =6 and 7 was high enough for clinical application of radioembolic therapy of cancer.

Original language	English
Article number	192003
Journal	IOP Conference Series: Materials Science and Engineering
Volume	18
Issue number	SYMPOSIUM 13
DOIs	https://doi.org/10.1088/1757-899X/18/19/192003
Publication status	Published - 2011
Event	3rd International Congress on Ceramics, ICC3 - Osaka, Japan Duration: 2010 Nov 14 → 2010 Nov 18

ASJC Scopus subject areas

Materials Science(all)
Engineering(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1088/1757-899X/18/19/192003

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title = "Novel synthesis of yttrium phosphate microspheres for radioembolization of cancer",

abstract = "Chemically durable microspheres containing yttrium and/or phosphorus are useful for intra-arterial radiotherapy. In the present study, we attempted to prepare yttrium phosphate (YPO4) microspheres with high chemical durability as well as smooth surface and investigated their chemical durability in simulated body environment. YPO4 microspheres with smooth surface around 25 μm were successfully obtained, when gelatin droplets containing YPO4 precursor was cooled to be solidified in water-in-oil emulsion and then heat-treated at 1100°C. The chemical durability of the heat-treated microspheres in simulated body fluid at pH =6 and 7 was high enough for clinical application of radioembolic therapy of cancer.",

author = "M. Kawashita and N. Matsui and Z. Li and T. Miyazaki",

year = "2011",

doi = "10.1088/1757-899X/18/19/192003",

language = "English",

volume = "18",

journal = "IOP Conference Series: Materials Science and Engineering",

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note = "3rd International Congress on Ceramics, ICC3 ; Conference date: 14-11-2010 Through 18-11-2010",

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TY - JOUR

T1 - Novel synthesis of yttrium phosphate microspheres for radioembolization of cancer

AU - Kawashita, M.

AU - Matsui, N.

AU - Li, Z.

AU - Miyazaki, T.

PY - 2011

Y1 - 2011

N2 - Chemically durable microspheres containing yttrium and/or phosphorus are useful for intra-arterial radiotherapy. In the present study, we attempted to prepare yttrium phosphate (YPO4) microspheres with high chemical durability as well as smooth surface and investigated their chemical durability in simulated body environment. YPO4 microspheres with smooth surface around 25 μm were successfully obtained, when gelatin droplets containing YPO4 precursor was cooled to be solidified in water-in-oil emulsion and then heat-treated at 1100°C. The chemical durability of the heat-treated microspheres in simulated body fluid at pH =6 and 7 was high enough for clinical application of radioembolic therapy of cancer.

AB - Chemically durable microspheres containing yttrium and/or phosphorus are useful for intra-arterial radiotherapy. In the present study, we attempted to prepare yttrium phosphate (YPO4) microspheres with high chemical durability as well as smooth surface and investigated their chemical durability in simulated body environment. YPO4 microspheres with smooth surface around 25 μm were successfully obtained, when gelatin droplets containing YPO4 precursor was cooled to be solidified in water-in-oil emulsion and then heat-treated at 1100°C. The chemical durability of the heat-treated microspheres in simulated body fluid at pH =6 and 7 was high enough for clinical application of radioembolic therapy of cancer.

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U2 - 10.1088/1757-899X/18/19/192003

DO - 10.1088/1757-899X/18/19/192003

M3 - Conference article

AN - SCOPUS:80052081186

SN - 1757-8981

VL - 18

JO - IOP Conference Series: Materials Science and Engineering

JF - IOP Conference Series: Materials Science and Engineering

IS - SYMPOSIUM 13

M1 - 192003

T2 - 3rd International Congress on Ceramics, ICC3

Y2 - 14 November 2010 through 18 November 2010

ER -

Novel synthesis of yttrium phosphate microspheres for radioembolization of cancer

Abstract

ASJC Scopus subject areas

UN SDGs

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