Novel single nucleotide polymorphism of the CYP2A13 gene in Japanese individuals

Yuichiro Tamaki; Masashi Honda; Yuka Muroi; Tomio Arai; Haruhiko Sugimura; Yoichi Matsubara; Shuichi Kanno; Masaaki Ishikawa; Noriyasu Hirasawa; Masahiro Hiratsuka

doi:10.2133/dmpk.DMPK-11-SC-033

Novel single nucleotide polymorphism of the CYP2A13 gene in Japanese individuals

Yuichiro Tamaki, Masashi Honda, Yuka Muroi, Tomio Arai, Haruhiko Sugimura, Yoichi Matsubara, Shuichi Kanno, Masaaki Ishikawa, Noriyasu Hirasawa, Masahiro Hiratsuka

PHA - Pharmacy

Research output: Contribution to journal › Article

6 Citations (Scopus)

Abstract

Cytochrome P450 2A13 (CYP2A13) is a human CYP enzyme that is selectively expressed in the respiratory tract. It plays an active role in the metabolic activation of a tobacco-specific procarcinogen. In this study, the entire coding sequence and the exon-intron junctions of the CYP2A13 gene obtained from 395 Japanese individuals were screened for genetic polymorphisms. Eight genetic polymorphisms were found, of which seven gave rise to known variant alleles: CYP2A13*2, CYP2A13*3, CYP2A13*4, CYP2A13*6, and CYP2A13*7. We identified a novel single nucleotide polymorphism (SNP), 5792T>C, in exon 7 that caused an amino acid substitution (Ile331Thr). One of the 395 individuals included in the study was heterozygous for the variant allele, and therefore, the frequency of the allele in the study population was 0.13%.

Original language	English
Pages (from-to)	544-547
Number of pages	4
Journal	Drug metabolism and pharmacokinetics
Volume	26
Issue number	5
DOIs	https://doi.org/10.2133/dmpk.DMPK-11-SC-033
Publication status	Published - 2011

Keywords

CYP2A13
Genetic polymorphism
Japanese
SNP

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science
Pharmacology (medical)

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10.2133/dmpk.DMPK-11-SC-033

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Tamaki, Y., Honda, M., Muroi, Y., Arai, T., Sugimura, H., Matsubara, Y., Kanno, S., Ishikawa, M., Hirasawa, N., & Hiratsuka, M. (2011). Novel single nucleotide polymorphism of the CYP2A13 gene in Japanese individuals. Drug metabolism and pharmacokinetics, 26(5), 544-547. https://doi.org/10.2133/dmpk.DMPK-11-SC-033

Novel single nucleotide polymorphism of the CYP2A13 gene in Japanese individuals. / Tamaki, Yuichiro; Honda, Masashi; Muroi, Yuka; Arai, Tomio; Sugimura, Haruhiko; Matsubara, Yoichi; Kanno, Shuichi; Ishikawa, Masaaki; Hirasawa, Noriyasu ; Hiratsuka, Masahiro.

In: Drug metabolism and pharmacokinetics, Vol. 26, No. 5, 2011, p. 544-547.

Research output: Contribution to journal › Article

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AU - Matsubara, Yoichi

AU - Kanno, Shuichi

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