Novel role of toll-like receptors in Helicobacter pylori-induced gastric malignancy

Kaname Uno, Katsuaki Kato, Tooru Shimosegawa

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Helicobacter pylori (H. pylori) infects the human stomach during infancy and develops into chronic active inflammation. The majority of H. pylori tend to colonize within the mucous gel layer of the stomach. The stomach lacks its own immune function, thus innate immunity as the first line of defense is vital for specific immunity against H. pylori. We review recent discoveries in the pathophysiologic roles of toll-like receptors (TLRs), mainly TLR2 and TLR4, in H. pylori -induced inflammation. In addition, the TLR pathways activated by H. pylori -induced inflammation have been shown to be closely associated not only with gastric carcinogenesis, but also with formation of the tumor microenvironment through the production of pro-inflammatory cytokines, chemokines, and reactive oxygen species. Although the correlation between single nucleotide polymorphisms of TLRs and gastric cancer risk remains unclear, a recent study demonstrated that STAT3-driven upregulation of TLR2 might promote gastric tumorigenesis independent of inflammation. Further research on the regulation of TLRs in H. pylori -associated gastric carcinogenesis will uncover diagnostic/predictive biomarkers and therapeutic targets for gastric cancer.

Original languageEnglish
Pages (from-to)5244-5251
Number of pages8
JournalWorld Journal of Gastroenterology
Volume20
Issue number18
DOIs
Publication statusPublished - 2014 May 14

Keywords

  • Damage-associated molecular patterns
  • Gastric cancer
  • Helicobacter pylori
  • Pathogen-associated molecular patterns
  • Toll like receptors

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Novel role of toll-like receptors in Helicobacter pylori-induced gastric malignancy'. Together they form a unique fingerprint.

  • Cite this