Novel regenerative therapy for acute kidney injury

Takafumi Toyohara, Kenji Osafune

Research output: Contribution to journalReview articlepeer-review


Acute kidney injury (AKI) is a renal disease that is associated with high mortality. Current treatments mostly rely on supportive therapies and do not directly target the disease. Regenerative medicine, however, offers potentially direct AKI therapy through two strategies: Cell transplantation and kidney reconstruction. Regarding cell transplantation, several cell types are potential sources, including hematopoietic stem cells, mesenchymal stem cells, and renal stem/progenitor cells within the adult kidney tissue or derived from human-induced pluripotent stem cells (iPSCs). On the other hand, kidney reconstruction could provide a curative treatment for severe AKI and consequent chronic kidney disease (CKD). Many methods have been proposed for the kidney reconstruction, including self-organization, blastocyst complementation, decellularization, and bioartificial kidneys. However, there are still a number of obstacles to overcome before reconstructed kidneys reach clinical use. In this review, we summarize the recent progresses in cell transplantation and kidney reconstruction as strategies to treating AKI.

Original languageEnglish
Article number34
JournalRenal Replacement Therapy
Issue number1
Publication statusPublished - 2016 Aug 22


  • Acute Kidney Injury
  • Acute Tubular Necrosis
  • Paracrine Factor
  • Renal Tubule
  • Side Population Cell

ASJC Scopus subject areas

  • Urology
  • Transplantation
  • Nephrology

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