Novel rat model of stress urinary incontinence with a retroflexed bladder

Naoki Kawamorita, Yasuhiro Kaiho, Haruo Nakagawa, Minoru Miyazato, Mabumi Matsushita, Yoichi Arai

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Introduction and hypothesis: We created a rat model with a retroflexed bladder that mimicked the loss of the posterior urethrovesical angle and compared the results with sham-surgery rats for the establishment of rat models of stress urinary incontinence. Methods: The retroflexed bladder was created by stitching the bladder posteriorly to the psoas muscle. Sneeze-induced urethral pressure response and urethral baseline pressure were measured using a microtip-transducer catheter and leak point pressures induced by sneezing, the Crede maneuver, and the vertical tilt table method were measured via a supra-pubic cystostomy. Results: In rats with a retroflexed bladder, both urethral pressure response and sneeze-induced leak point pressure were significantly decreased. Conclusion: A retroflexed bladder may cause stress urinary incontinence by attenuating the sneeze-induced active urethral closure mechanism. Urethral pressure response restored by resumption of the posterior urethrovesical angle would explain why no sling tension is needed to treat the stress urinary incontinence.

Original languageEnglish
Pages (from-to)595-601
Number of pages7
JournalInternational Urogynecology Journal
Volume21
Issue number5
DOIs
Publication statusPublished - 2010 May

Keywords

  • Leak point pressure
  • Posterior urethrovesical angle
  • Rat model
  • Sling
  • Sneeze
  • Stress urinary incontinence

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Urology

Fingerprint Dive into the research topics of 'Novel rat model of stress urinary incontinence with a retroflexed bladder'. Together they form a unique fingerprint.

  • Cite this