Novel polymer biomaterials and interfaces inspired from cell membrane functions

Kazuhiko Ishihara, Yusuke Goto, Madoka Takai, Ryosuke Matsuno, Yuuki Inoue, Tomohiro Konno

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

Background: Materials with excellent biocompatibility on interfaces between artificial system and biological system are needed to develop any equipments and devices in bioscience, bioengineering and medicinal science. Suppression of unfavorable biological response on the interface is most important for understanding real functions of biomolecules on the surface. So, we should design and prepare such biomaterials. Scoop of review: One of the best ways to design the biomaterials is generated from mimicking a cell membrane structure. It is composed of a phospholipid bilayered membrane and embedded proteins and polysaccharides. The surface of the cell membrane-like structure is constructed artificially by molecular integration of phospholipid polymer as platform and conjugated biomolecules. Here, it is introduced as the effectiveness of biointerface with highly biological functions observed on artificial cell membrane structure. Major conclusions: Reduction of nonspecific protein adsorption is essential for suppression of unfavorable bioresponse and achievement of versatile biomedical applications. Simultaneously, bioconjugation of biomolecules on the phospholipid polymer platform is crucial for a high-performance interface. General significance: The biointerfaces with both biocompatibility and biofunctionality based on biomolecules must be installed on advanced devices, which are applied in the fields of nanobioscience and nanomedicine. This article is part of a Special Issue entitled Nanotechnologies - Emerging Applications in Biomedicine.

Original languageEnglish
Pages (from-to)268-275
Number of pages8
JournalBiochimica et Biophysica Acta - General Subjects
Volume1810
Issue number3
DOIs
Publication statusPublished - 2011 Mar

Keywords

  • Biocompatibility
  • Biointerface
  • Biomaterial
  • Cell membrane
  • Phospholipid polymer

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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