Novel modulators for body weight changes induced by fasting and re-feeding in mice

Katsunori Nonogaki, Yukie Ohba, Makiko Sumii, Mamoru Wakameda, Tomohiro Tamari

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Catch-up weight gain after malnutrition is a risk factor for metabolic syndrome. Here we show that social isolation enhanced fasting-induced weight loss and suppressed weight gain induced by re-feeding for 6 days following a 24-h fast in prepubertal wild-type mice. These effects of social isolation on weight gain were not associated with significant changes in daily average food consumption. Under the same housing condition, genetic deletion of β-endorphin reduced the fasting-induced weight loss and enhanced the re-feeding-induced weight gain in prepubertal mice. These effects of social isolation or genetic deletion of β-endorphin on these weight changes were attenuated and reversed in postpubertal mice. Moreover, genetic deletion of β-endorphin attenuated these effects of social isolation on the catch-up weight gain in prepubertal mice and reversed them in postpubertal mice. Thus, social isolation, endogenous β-endorphin, and age can be novel modulators for body weight changes induced by fasting and re-feeding in mice.

Original languageEnglish
Pages (from-to)249-254
Number of pages6
JournalBiochemical and biophysical research communications
Volume378
Issue number2
DOIs
Publication statusPublished - 2009 Jan 9

Keywords

  • Age
  • Body weight
  • Catch-up weight gain
  • Fasting
  • Re-feeding
  • Social isolation
  • β-Endorphin

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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