Novel lysophosphoplipid receptors: their structure and function

Kumiko Makide, Akiharu Uwamizu, Yuji Shinjo, Jun Ishiguro, Michiyo Okutani, Asuka Inoue, Junken Aoki

Research output: Contribution to journalReview article

57 Citations (Scopus)

Abstract

It is now accepted that lysophospholipids (LysoGPs) have a wide variety of functions as lipid mediators that are exerted through G protein-coupled receptors (GPCRs) specific to each lysophospholipid. While the roles of some LysoGPs, such as lysophosphatidic acid and sphingosine 1-phosphate, have been thoroughly examined, little is known about the roles of several other LysoGPs, such as lysophosphatidylserine (LysoPS), lysophosphatidylthreonine, lysophosphatidylethanolamine, lysophosphatidylinositol (LPI), and lysophosphatidylglycerol. Recently, a GPCR was found for LPI (GPR55) and three GPCRs (GPR34/LPS1, P2Y10/LPS2, and GPR174/LPS3) were found for LysoPS. In this review, we focus on these newly identified GPCRs and summarize the actions of LysoPS and LPI as lipid mediators.

Original languageEnglish
Pages (from-to)1986-1995
Number of pages10
JournalJournal of lipid research
Volume55
Issue number10
DOIs
Publication statusPublished - 2014 Oct 1

Keywords

  • GPCR
  • LPI
  • LysoPS

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Cell Biology

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  • Cite this

    Makide, K., Uwamizu, A., Shinjo, Y., Ishiguro, J., Okutani, M., Inoue, A., & Aoki, J. (2014). Novel lysophosphoplipid receptors: their structure and function. Journal of lipid research, 55(10), 1986-1995. https://doi.org/10.1194/jlr.R046920