Novel ketolide antibacterial agents - With special reference to telithromycin

Matsuhisa Inoue, Mitsuo Kaku, Takeshi Nishino, Yoichi Hirakata, Shigeru Kohno

Research output: Contribution to journalArticlepeer-review


Ketolide antibacterial agents have been under development worldwide as a new class of antibacterial agents. Initial research and development of ketolide antibacterials has been aimed at identifying characteristic properties of ketolide compounds, and telithromycin, the agent that has been developed the furthest has been used clinically in many countries. The chemical structure of ketolides is characterized by a ketone group at position-8, and bacteriologicaly they exhibit potent antibacterial activity against pathogenic bacteria of respiratory and otorhinological infections, such as gram-positive cocci, Haemophilus, atypical microorganisms, and intracellularly parasitic bacteria. Telithromycins characterized by potent activity against penicillin-, macrolide- and quinolone-resistant Streptococcus pneumoniae, and there is no cross-resistance with other antibacterial agents.

Original languageEnglish
Pages (from-to)278-288
Number of pages11
JournalJapanese Journal of Chemotherapy
Issue number5
Publication statusPublished - 2003 May 1


  • Telithromycin

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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