TY - JOUR
T1 - Novel insights into the interplay between apoptosis and autophagy
AU - Rikiishi, Hidemi
PY - 2012
Y1 - 2012
N2 - For several decades, apoptosis has taken center stage as the principal mechanism of programmed cell death (type I cell death) in mammalian tissues. Autophagic cell death (type II) is characterized by the massive accumulation of autophagic vacuoles in the cytoplasm of cells. The autophagic process is activated as an adaptive response to a variety of extracellular and intracellular stresses, including nutrient deprivation, hormonal or therapeutic treatment, pathogenic infection, aggregated and misfolded proteins, and damaged organelles. Increasing evidence indicates that autophagy is associated with a number of pathological processes, including cancer. The regulation of autophagy in cancer cells is complex since it can enhance cancer cell survival in response to certain stresses, while it can also act to suppress the initiation of cancer growth. This paper focused on recent advances regarding autophagy in cancer and the techniques currently available to manipulate autophagy.
AB - For several decades, apoptosis has taken center stage as the principal mechanism of programmed cell death (type I cell death) in mammalian tissues. Autophagic cell death (type II) is characterized by the massive accumulation of autophagic vacuoles in the cytoplasm of cells. The autophagic process is activated as an adaptive response to a variety of extracellular and intracellular stresses, including nutrient deprivation, hormonal or therapeutic treatment, pathogenic infection, aggregated and misfolded proteins, and damaged organelles. Increasing evidence indicates that autophagy is associated with a number of pathological processes, including cancer. The regulation of autophagy in cancer cells is complex since it can enhance cancer cell survival in response to certain stresses, while it can also act to suppress the initiation of cancer growth. This paper focused on recent advances regarding autophagy in cancer and the techniques currently available to manipulate autophagy.
UR - http://www.scopus.com/inward/record.url?scp=84859766593&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84859766593&partnerID=8YFLogxK
U2 - 10.1155/2012/317645
DO - 10.1155/2012/317645
M3 - Review article
C2 - 22496691
AN - SCOPUS:84859766593
JO - International Journal of Cell Biology
JF - International Journal of Cell Biology
SN - 1687-8876
M1 - 317645
ER -