Abstract
Insulinomas can be induced in experimental animals by the combined administration of diabetogenic agents with polyadenosine diphosphate (polyADP)-ribose synthetase inhibitors. A complementary DNA (cDNA) library that was constructed from streptozotocin-nicotinamide-induced rat insulinomas has been found to contain a novel gene encoding a basic protein of 145 amino acids. The gene was expressed in alloxan-nicotinamide-induced insulinomas as well as in streptozotocin-nicotinamide-induced insulinomas but not in normal pancreatic islets or in regenerating islets. This indicates that the activation of the gene designated rig, i.e., rat insulinoma gene, may be a general feature of pancreatic β-cell transformation.
Original language | English |
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Pages (from-to) | 1178-1180 |
Number of pages | 3 |
Journal | Diabetes |
Volume | 35 |
Issue number | 10 |
DOIs | |
Publication status | Published - 1986 |
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism