Novel gene activated in rat insulinomas

S. Takasawa, H. Yamamoto, K. Terazono, H. Okamoto

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Insulinomas can be induced in experimental animals by the combined administration of diabetogenic agents with polyadenosine diphosphate (polyADP)-ribose synthetase inhibitors. A complementary DNA (cDNA) library that was constructed from streptozotocin-nicotinamide-induced rat insulinomas has been found to contain a novel gene encoding a basic protein of 145 amino acids. The gene was expressed in alloxan-nicotinamide-induced insulinomas as well as in streptozotocin-nicotinamide-induced insulinomas but not in normal pancreatic islets or in regenerating islets. This indicates that the activation of the gene designated rig, i.e., rat insulinoma gene, may be a general feature of pancreatic β-cell transformation.

Original languageEnglish
Pages (from-to)1178-1180
Number of pages3
JournalDiabetes
Volume35
Issue number10
DOIs
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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