Novel fluorescent analogues for transmembrane movement study of polyprenyl phosphates

Koichi Koseki; Satoshi Yamashita; Seiji Takahashi; Tanetoshi Koyama

doi:10.1016/j.bmcl.2006.11.049

Novel fluorescent analogues for transmembrane movement study of polyprenyl phosphates

Koichi Koseki, Satoshi Yamashita, Seiji Takahashi, Tanetoshi Koyama

ENG - Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

In order to investigate the transmembrane movement of polyprenyl phosphate across biological membranes, NBD (7-nitrobenz-2-oxa-1,3-diazol-4-yl)-labeled polyprenyl phosphate analogues were prepared. These analogues proved to be possible tools for a direct observation of the transmembrane flip-flop movement of polyprenyl phosphates by use of a sodium dithionite-quenching procedure.

Original language	English
Pages (from-to)	946-950
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	4
DOIs	https://doi.org/10.1016/j.bmcl.2006.11.049
Publication status	Published - 2007 Feb 15

Keywords

Flip-flop
Isoprenoid
NBD
Polyprenyl phosphate

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Organic Chemistry
Drug Discovery
Pharmaceutical Science

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10.1016/j.bmcl.2006.11.049

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title = "Novel fluorescent analogues for transmembrane movement study of polyprenyl phosphates",

abstract = "In order to investigate the transmembrane movement of polyprenyl phosphate across biological membranes, NBD (7-nitrobenz-2-oxa-1,3-diazol-4-yl)-labeled polyprenyl phosphate analogues were prepared. These analogues proved to be possible tools for a direct observation of the transmembrane flip-flop movement of polyprenyl phosphates by use of a sodium dithionite-quenching procedure.",

keywords = "Flip-flop, Isoprenoid, NBD, Polyprenyl phosphate",

author = "Koichi Koseki and Satoshi Yamashita and Seiji Takahashi and Tanetoshi Koyama",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Novel fluorescent analogues for transmembrane movement study of polyprenyl phosphates

AU - Koseki, Koichi

AU - Yamashita, Satoshi

AU - Takahashi, Seiji

AU - Koyama, Tanetoshi

PY - 2007/2/15

Y1 - 2007/2/15

N2 - In order to investigate the transmembrane movement of polyprenyl phosphate across biological membranes, NBD (7-nitrobenz-2-oxa-1,3-diazol-4-yl)-labeled polyprenyl phosphate analogues were prepared. These analogues proved to be possible tools for a direct observation of the transmembrane flip-flop movement of polyprenyl phosphates by use of a sodium dithionite-quenching procedure.

AB - In order to investigate the transmembrane movement of polyprenyl phosphate across biological membranes, NBD (7-nitrobenz-2-oxa-1,3-diazol-4-yl)-labeled polyprenyl phosphate analogues were prepared. These analogues proved to be possible tools for a direct observation of the transmembrane flip-flop movement of polyprenyl phosphates by use of a sodium dithionite-quenching procedure.

KW - Flip-flop

KW - Isoprenoid

KW - NBD

KW - Polyprenyl phosphate

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UR - http://www.scopus.com/inward/citedby.url?scp=33846618640&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2006.11.049

DO - 10.1016/j.bmcl.2006.11.049

M3 - Article

C2 - 17157015

AN - SCOPUS:33846618640

VL - 17

SP - 946

EP - 950

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 4

ER -

Novel fluorescent analogues for transmembrane movement study of polyprenyl phosphates

Abstract

Keywords

ASJC Scopus subject areas

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