Novel fluorescent analogues for transmembrane movement study of polyprenyl phosphates

Koichi Koseki, Satoshi Yamashita, Seiji Takahashi, Tanetoshi Koyama

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

In order to investigate the transmembrane movement of polyprenyl phosphate across biological membranes, NBD (7-nitrobenz-2-oxa-1,3-diazol-4-yl)-labeled polyprenyl phosphate analogues were prepared. These analogues proved to be possible tools for a direct observation of the transmembrane flip-flop movement of polyprenyl phosphates by use of a sodium dithionite-quenching procedure.

Original languageEnglish
Pages (from-to)946-950
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number4
DOIs
Publication statusPublished - 2007 Feb 15

Keywords

  • Flip-flop
  • Isoprenoid
  • NBD
  • Polyprenyl phosphate

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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