Novel fluorescent analogues for transmembrane movement study of polyprenyl phosphates

Koichi Koseki; Satoshi Yamashita; Seiji Takahashi; Tanetoshi Koyama

doi:10.1016/j.bmcl.2006.11.049

Novel fluorescent analogues for transmembrane movement study of polyprenyl phosphates

Koichi Koseki, Satoshi Yamashita, Seiji Takahashi, Tanetoshi Koyama

ENG - Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

In order to investigate the transmembrane movement of polyprenyl phosphate across biological membranes, NBD (7-nitrobenz-2-oxa-1,3-diazol-4-yl)-labeled polyprenyl phosphate analogues were prepared. These analogues proved to be possible tools for a direct observation of the transmembrane flip-flop movement of polyprenyl phosphates by use of a sodium dithionite-quenching procedure.

Original language	English
Pages (from-to)	946-950
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	4
DOIs	https://doi.org/10.1016/j.bmcl.2006.11.049
Publication status	Published - 2007 Feb 15

Keywords

Flip-flop
Isoprenoid
NBD
Polyprenyl phosphate

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Organic Chemistry
Drug Discovery
Pharmaceutical Science

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T1 - Novel fluorescent analogues for transmembrane movement study of polyprenyl phosphates

AU - Koseki, Koichi

AU - Yamashita, Satoshi

AU - Takahashi, Seiji

AU - Koyama, Tanetoshi

PY - 2007/2/15

Y1 - 2007/2/15

N2 - In order to investigate the transmembrane movement of polyprenyl phosphate across biological membranes, NBD (7-nitrobenz-2-oxa-1,3-diazol-4-yl)-labeled polyprenyl phosphate analogues were prepared. These analogues proved to be possible tools for a direct observation of the transmembrane flip-flop movement of polyprenyl phosphates by use of a sodium dithionite-quenching procedure.

AB - In order to investigate the transmembrane movement of polyprenyl phosphate across biological membranes, NBD (7-nitrobenz-2-oxa-1,3-diazol-4-yl)-labeled polyprenyl phosphate analogues were prepared. These analogues proved to be possible tools for a direct observation of the transmembrane flip-flop movement of polyprenyl phosphates by use of a sodium dithionite-quenching procedure.

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KW - Isoprenoid

KW - NBD

KW - Polyprenyl phosphate

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JO - Bioorganic and Medicinal Chemistry Letters

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