Novel elastic material from collagen for tissue engineering

Shunji Yunoki, Kazuo Mori, Takeshi Suzuki, Nobuhiro Nagai, Masanobu Munekata

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Elastic collagen gel (e-gel) was prepared from salmon atelocollagen fibrillar gel reinforced by 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) mediated cross-linking (f-gel). The preparation consisted of a simple heat treatment of the f-gel at 80°C, in which the f-gel drastically shrank and the collagen fibril structure was deformed. The e-gel obtained showed rubber-like elasticity; its stress-strain behavior little changed through repeated stretching. The elongation at the breaking point was approximately 230%. Furthermore, normal human osteoblasts showed good attachment and proliferation on the e-gel. These results suggest its potential to be utilized for the development of tissue engineering.

Original languageEnglish
Pages (from-to)1369-1375
Number of pages7
JournalJournal of Materials Science: Materials in Medicine
Issue number7
Publication statusPublished - 2007 Jul 1
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Chemical Engineering(all)


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