Novel effects of a single administration of ferulic acid on the regulation of blood pressure and the hepatic lipid metabolic profile in stroke-prone spontaneously hypertensive rats

Ardiansyah, Yusuke Ohsaki, Hitoshi Shirakawa, Takuya Koseki, Michio Komai

Research output: Contribution to journalArticlepeer-review

84 Citations (Scopus)

Abstract

We studied the effects of a single oral administration of ferulic acid (FA) on the blood pressure (BP) and lipid profile in stroke-prone spontaneously hypertensive rats (SHRSP). Male 12-week-old SHRSP were administered FA (9.5 mg/kg of body weight) and distilled water as the control (C) (1 mL) via a gastric tube. The hypotensive effect of FA was observed at the lowest value after 2 h administration. A decrease in the angiotensin-1-converting enzyme (ACE) activity in the plasma corresponded well with the reduction of BP. Plasma total cholesterol and triglyceride levels were lower after 2 h administration. The mRNA expression of genes involved in lipid and drug metabolism was downregulated in the FA group. These results suggest that oral administration of FA appears beneficial in improving hypertension and hyperlipidemia.

Original languageEnglish
Pages (from-to)2825-2830
Number of pages6
JournalJournal of Agricultural and Food Chemistry
Volume56
Issue number8
DOIs
Publication statusPublished - 2008 Apr 23

Keywords

  • Blood pressure
  • Ferulic acid
  • Hepatic gene expression
  • Lipid profile

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

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